BACKGROUND The core of the mammalian circadian clock mechanism is a time-delayed
transcription-translation feedback loop (TTFL), which influences the transcription and …

Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Ageing leads to a functional deterioration of many brain systems, including the circadian
clock—an internal time-keeping system that generates∼ 24-hour rhythms in physiology and …

Breast cancer is the leading cause of cancer death among women worldwide, and there is
only a limited explanation of why. Risk is highest in the most industrialized countries but also …

Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …

Circadian rhythms govern a remarkable variety of metabolic and physiological functions.
Accumulating epidemiological and genetic evidence indicates that the disruption of …

Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon
serial transplantation in animal models, and elimination of this cell population is required for …

Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological
and behavioral functions of almost all species. This pattern is due to a fundamental …

Background The aging process is not univocal, both body and brain age. Neurological
disorders are a major cause of disability and death worldwide. According to the Global …