Sphingolipids are components of the lipid rafts in plasma membranes, which are important
for proper function of podocytes, a key element of the glomerular filtration barrier. Research …

In the past 15 years, major advances have been made in understanding the role of lipids in
podocyte biology. First, susceptibility to focal segmental glomerulosclerosis (FSGS) and …

Vascular endothelial growth factor and its receptors, FLK1/KDR and FLT1, are key
regulators of angiogenesis. Unlike FLK1/KDR, the role of FLT1 has remained elusive. FLT1 …

We recently found that albuminuria levels in patients with minimal change disease (MCD)
and focal segmental glomerulosclerosis (FSGS) inversely correlate with glycosphingolipid …

Introduction Increased vascular permeability represents one of the hallmarks of sepsis. In
the kidney, vascular permeability is strictly regulated by the'glomerular filtration …

Metabolic changes associated with diabetes are reported to lead to the onset of early-stage
diabetic nephropathy (DN). Furthermore, lipotoxicity is implicated in renal dysfunction. Most …

Sphingolipids are well-recognized as major players in the pathogenesis of many human
diseases, including chronic kidney disease. The kidney is a very sensitive organ to …

Podocyte health is vital for maintaining proper glomerular filtration in the kidney.
Interdigitating foot processes from podocytes form slit diaphragms which regulate the …

Background Glycolipids on cell membrane rafts play various roles by interacting with
glycoproteins. Recently, it was reported that the glycolipid GM3 is expressed in podocytes …

D iabetes is a debilitating chronic disease that has no cure and can only be managed by
pharmaceutical or nutritional interventions. Worldwide, the incidence of diabetes and …