Cell death is a normal physiological process within cells that involves multiple pathways,
such as normal DNA damage, cell cycle arrest, and programmed cell death (PCD). Cell …

Venetoclax is a strongly effective B-cell lymphoma-2 inhibitor (BCL-2) with an ability to
selectively restore the apoptotic potential of cancerous cells. It has been proven that in …

Abstract CBFA2T3-GLIS2 is a fusion oncogene found in pediatric acute megakaryoblastic
leukemia that is associated with a poor prognosis. We establish a model of CBFA2T3-GLIS2 …

Recently, the development of protein degraders (protein-degrading compounds) has
prominently progressed. There are two remarkable classes of protein degraders: proteolysis …

Targeted therapeutics for high-risk cancers remain an unmet medical need. Here we report
the results of a large-scale screen of over 11,000 molecules for their ability to inhibit the …

Background Several fusion oncogenes showing a higher incidence in pediatric acute
myeloid leukemia (AML) are associated with heterogeneous megakaryoblastic and other …

Abstract Treatment of relapsed and refractory myeloid leukemia in Down syndrome (r/r ML‐
DS) poses significant challenges, as prognosis is dire and there is no established standard …

Acute myeloid leukemia (AML), an aggressive malignancy of hematopoietic stem cells, is
characterized by the blockade of cell differentiation, uncontrolled proliferation, and cell …

Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription
factor that is a key mediator of lipid metabolism and metabolic stress in the liver …

Venetoclax selectively inhibits BCL-2 and restores apoptotic signaling of hematological
malignant cells. Venetoclax in combination with hypomethylating and low-dose cytotoxic …