Beyond vitamin D (VD) effect on bone homeostasis, numerous physiological functions in
human health have been described for this versatile prohormone. In 2016, 95% of the …

Vitamin D is well known to exert multiple functions in bone biology, autoimmune diseases,
cell growth, inflammation or neuromuscular and other immune functions. It is a fat-soluble …

Hepatic osteodystrophy (HOD) is a metabolic bone disease that is often associated with
chronic liver disease and is marked by bone loss. Here, we demonstrate that hepatic …

In recent years, researchers have become focused on the relationship between lipids and
bone metabolism balance. Moreover, many diseases related to lipid metabolism disorders …

Histological alterations often constitute a fingerprint of toxicity and diseases. The extent to
which these alterations are cause or consequence of compromised organ function, and the …

Reversibility of hepatic fibrosis is an intrinsic response to chronic injury, and with on-going
damage, fibrosis can progress to its end-stage consequence, cirrhosis. Non-invasive and …

Background Increasing attention to liver-bone crosstalk has spurred interest in targeted
interventions for various forms of osteoporosis. Liver injury induced by different liver …

Bone tissue undergoes constant remodeling and healing when fracture happens, in order to
ensure its structural integrity. In order to better understand open biological and clinical …

Almost all patients with chronic liver diseases (CLD) show altered bone metabolism.
Depending on the etiology, this manifests in a severe osteoporosis in up to 75% of the …

Transforming growth factor β (TGF-β) is a critical regulator of bone density owing to its
multiple effects on cell growth and differentiation. Recently, we have shown that TGF-β 1 …