[HTML][HTML] Engineering the multiscale complexity of vascular networks
The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …
nutrients through vascular networks that pervade nearly all tissues in the body …
Basic and therapeutic aspects of angiogenesis updated
G Eelen, L Treps, X Li, P Carmeliet - Circulation research, 2020 - Am Heart Assoc
All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …
[HTML][HTML] Single-cell transcriptome atlas of murine endothelial cells
The heterogeneity of endothelial cells (ECs) across tissues remains incompletely
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …
[HTML][HTML] Multiorgan-on-a-chip: a systemic approach to model and decipher inter-organ communication
N Picollet-D'hahan, A Zuchowska, I Lemeunier… - Trends in …, 2021 - cell.com
Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which
human health research is conducted. After briefly reviewing the need for comprehensive …
human health research is conducted. After briefly reviewing the need for comprehensive …
The endothelium–bone axis in development, homeostasis and bone and joint disease
J Tuckermann, RH Adams - Nature Reviews Rheumatology, 2021 - nature.com
Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …
processes such as tissue oxygenation, metabolism and immune surveillance. The …
Single-cell RNA sequencing unveils unique transcriptomic signatures of organ-specific endothelial cells
Background: Endothelial cells (ECs) display considerable functional heterogeneity
depending on the vessel and tissue in which they are located. Whereas these functional …
depending on the vessel and tissue in which they are located. Whereas these functional …
[HTML][HTML] Vascular endothelial cells: heterogeneity and targeting approaches
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …
[HTML][HTML] Hallmarks of endothelial cell metabolism in health and disease
X Li, X Sun, P Carmeliet - Cell metabolism, 2019 - cell.com
In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the
orders of growth factors if these cells would accordingly adapt their metabolism. Ten years …
orders of growth factors if these cells would accordingly adapt their metabolism. Ten years …
[HTML][HTML] Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in …
Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa)
progression and dissemination. Insight in cell-to-cell communication networks provides new …
progression and dissemination. Insight in cell-to-cell communication networks provides new …
[HTML][HTML] An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …