Regioselective synthesis of 5-trifluoromethylpyrazoles by [3+ 2] cycloaddition of nitrile imines and 2-bromo-3, 3, 3-trifluoropropene
H Zeng, X Fang, Z Yang, C Zhu… - The Journal of Organic …, 2021 - ACS Publications
A general and practical method for the synthesis of 5-trifluoromethylpyrazoles is reported
that occurs by the coupling of hydrazonyl chlorides with environmentally friendly and large …
that occurs by the coupling of hydrazonyl chlorides with environmentally friendly and large …
Click 1, 2, 3-triazoles in drug discovery and development: From the flask to the clinic?
After 20 years since its conception, click chemistry has come of age and we believe the time
has come to evaluate if the copper-catalyzed azide alkyne cycloaddition (CuCAAC) reaction …
has come to evaluate if the copper-catalyzed azide alkyne cycloaddition (CuCAAC) reaction …
Store-operated calcium entry as a therapeutic target in acute pancreatitis: discovery and development of drug-like SOCE inhibitors
M Serafini, C Cordero-Sanchez… - Journal of Medicinal …, 2020 - ACS Publications
Store-operated calcium entry (SOCE) is important in the maintenance of calcium
homeostasis and alterations in this mechanism are responsible for several pathological …
homeostasis and alterations in this mechanism are responsible for several pathological …
Pyrtriazoles, a novel class of store-operated calcium entry modulators: discovery, biological profiling, and in vivo proof-of-concept efficacy in acute pancreatitis
B Riva, A Griglio, M Serafini… - Journal of medicinal …, 2018 - ACS Publications
In recent years, channels that mediate store-operated calcium entry (SOCE, ie, the ability of
cells to sense a decrease in endoplasmic reticulum luminal calcium and induce calcium …
cells to sense a decrease in endoplasmic reticulum luminal calcium and induce calcium …
1, 2, 4-Oxadiazole-Bearing pyrazoles as metabolically stable modulators of store-operated calcium entry
Store-operated calcium entry (SOCE) is a pivotal mechanism in calcium homeostasis, and,
despite still being under investigation, its dysregulation is known to be associated with …
despite still being under investigation, its dysregulation is known to be associated with …
Discovery and development of small molecules targeting IDO1 and SOCE
M Serafini - 2021 - iris.uniupo.it
My PhD thesis is focused on two main projects: the discovery of Store-Operated Calcium
Entry (SOCE) modulators and the development of indoleamine 2, 3-dioxygenase-1 (IDO1) …
Entry (SOCE) modulators and the development of indoleamine 2, 3-dioxygenase-1 (IDO1) …