Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Mitogen-activated protein kinases (MAPKs) have been the focus of many studies over the
past several decades, but the understanding of one subgroup of MAPKs, orthologs of …

Osteoarthritis (OA) is always characterized as excessive reactive oxygen species (ROS)
inside articular cavity. Mimicking natural metalloenzymes with metal ions as the active …

Oncogene-induced senescence (OIS) is a persistent anti-proliferative response that acts as
a barrier against malignant transformation. During OIS, cells undergo dynamic remodeling …

oxoguanine (8-oxoG) based DNA damage is the most common type of DNA damage which
greatly affect gene expression. Therefore, accurate quantification of 8-oxoG based DNA …

Age-related neurodegenerative diseases accompanied by learning and memory deficits are
growing in prevalence due to population aging. Cellular oxidative stress is a common …

There are many gynecological diseases, among which breast cancer (BC), cervical cancer
(CC), endometriosis (EMs), and polycystic ovary syndrome (PCOS) are common and difficult …

Extracellular signal‐regulated kinase 7 (ERK7), also known as ERK8 and MAPK15, is an
atypical member of the MAP kinase family. Compared with other MAP kinases, the biological …

Progeroid syndromes are characterized by clinical signs of premature ageing, which may
contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson …

The mitogen-activated protein kinase (MAPK) gene family performs crucial roles in cell
division, migration, development, apoptosis, inflammatory response, and abiotic and biotic …