Toward a general model of CD4+ T cell subset specification and memory cell formation
KC Osum, MK Jenkins - Immunity, 2023 - cell.com
In the past few decades, a number of transformative discoveries have been made regarding
memory CD8+ T cell biology; meanwhile, the CD4+ T cell field has lagged behind this …
memory CD8+ T cell biology; meanwhile, the CD4+ T cell field has lagged behind this …
Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics
Therapeutic monoclonal antibodies and their derivatives are key components of clinical
pipelines in the global biopharmaceutical industry. The availability of large datasets of …
pipelines in the global biopharmaceutical industry. The availability of large datasets of …
MHC-II neoantigens shape tumour immunity and response to immunotherapy
E Alspach, DM Lussier, AP Miceli, I Kizhvatov… - Nature, 2019 - nature.com
The ability of the immune system to eliminate and shape the immunogenicity of tumours
defines the process of cancer immunoediting. Immunotherapies such as those that target …
defines the process of cancer immunoediting. Immunotherapies such as those that target …
Predicting HLA class II antigen presentation through integrated deep learning
Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II
molecules would be valuable for vaccine development and cancer immunotherapies …
molecules would be valuable for vaccine development and cancer immunotherapies …
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes
J Racle, J Michaux, GA Rockinger, M Arnaud… - Nature …, 2019 - nature.com
Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II)
have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased …
have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased …
Evolutionary pressure against MHC class II binding cancer mutations
The anti-cancer immune response against mutated peptides of potential immunological
relevance (neoantigens) is primarily attributed to MHC-I-restricted cytotoxic CD8+ T cell …
relevance (neoantigens) is primarily attributed to MHC-I-restricted cytotoxic CD8+ T cell …
Systematically benchmarking peptide-MHC binding predictors: From synthetic to naturally processed epitopes
W Zhao, X Sher - PLoS computational biology, 2018 - journals.plos.org
A number of machine learning-based predictors have been developed for identifying
immunogenic T-cell epitopes based on major histocompatibility complex (MHC) class I and II …
immunogenic T-cell epitopes based on major histocompatibility complex (MHC) class I and II …
Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
JS Dolina, J Lee, SE Brightman… - The Journal of …, 2023 - Am Soc Clin Investig
Therapeutic benefit to immune checkpoint blockade (ICB) is currently limited to the subset of
cancers thought to possess a sufficient tumor mutational burden (TMB) to allow for the …
cancers thought to possess a sufficient tumor mutational burden (TMB) to allow for the …
Cancer neoantigens: challenges and future directions for prediction, prioritization, and validation
Prioritization of immunogenic neoantigens is key to enhancing cancer immunotherapy
through the development of personalized vaccines, adoptive T cell therapy, and the …
through the development of personalized vaccines, adoptive T cell therapy, and the …
Identification and validation of 174 COVID-19 vaccine candidate epitopes reveals low performance of common epitope prediction tools
M Prachar, S Justesen, DB Steen-Jensen… - Scientific reports, 2020 - nature.com
The outbreak of SARS-CoV-2 (2019-nCoV) virus has highlighted the need for fast and
efficacious vaccine development. Stimulation of a proper immune response that leads to …
efficacious vaccine development. Stimulation of a proper immune response that leads to …