Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Integrating neurons into digital systems may enable performance infeasible with silicon
alone. Here, we develop DishBrain, a system that harnesses the inherent adaptive …

Integrating neural cultures developed through synthetic biology methods with digital
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …

Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-
point range, but whether this process is gated by brain state is unknown. Here, we monitored …

It has become widely accepted that homeostatic and Hebbian plasticity mechanisms work
hand in glove to refine neural circuit function. Nonetheless, our understanding of how these …

Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and
memory. While the mechanisms underlying the induction of LTP ('learning') are well …

Synaptic plasticity is the capacity of a preexisting connection between two neurons to
change in strength as a function of neural activity. Because synaptic plasticity is the major …

Recognition of objects from sensory stimuli is essential for survival. To that end, sensory
networks in the brain must form object representations invariant to stimulus changes, such …

Hebbian plasticity, a synaptic mechanism which detects and amplifies co-activity between
neurons, is considered a key ingredient underlying learning and memory in the brain …