Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …

Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

Iron is an especially important redox-active cofactor in biology because of its ability to
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …

Jacob R. Ludwig received his BSc in chemistry in 2014 from Michigan State University,
where he performed research in the laboratory of Jetze Tepe. After graduation, he joined the …

The cytochrome P450 (CYP) AspB is involved in the biosynthesis of the diketopiperazine
(DKP) aspergilazine A. Tryptophan-linked dimeric DKP alkaloids are a large family of natural …

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

The cytochromes P450 (P450s or CYPs) constitute a large heme enzyme superfamily,
members of which catalyze the oxidative transformation of a wide range of organic …

Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …

P450 TleB catalyzes the oxidative cyclization of the dipeptide N-methylvalyl-tryptophanol
into indolactam V through selective intramolecular C–H bond amination at the indole C4 …