Regulating DNA replication in eukarya
K Siddiqui, KF On, JFX Diffley - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …
Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System
B Stynen, H Tournu, J Tavernier… - … and molecular biology …, 2012 - Am Soc Microbiol
The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …
[HTML][HTML] CDK substrate phosphorylation and ordering the cell cycle
S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK
complexes. However, it has been suggested that changes in the total level of CDK kinase …
complexes. However, it has been suggested that changes in the total level of CDK kinase …
Helicase activation and establishment of replication forks at chromosomal origins of replication
Many replication proteins assemble on the pre-RC-formed replication origins and constitute
the pre-initiation complex (pre-IC). This complex formation facilitates the conversion of Mcm2 …
the pre-initiation complex (pre-IC). This complex formation facilitates the conversion of Mcm2 …
Controlling DNA replication origins in response to DNA damage–inhibit globally, activate locally
M Yekezare, B Gómez-González… - Journal of cell …, 2013 - journals.biologists.com
DNA replication in eukaryotic cells initiates from multiple replication origins that are
distributed throughout the genome. Coordinating the usage of these origins is crucial to …
distributed throughout the genome. Coordinating the usage of these origins is crucial to …
TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways
CP Wardlaw, AM Carr, AW Oliver - DNA repair, 2014 - Elsevier
Human TopBP1 contains nine BRCT domains and functions in DNA replication initiation,
checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its …
checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its …
[HTML][HTML] Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1
The cellular response to DNA damage (DDR) that causes replication collapse and/or DNA
double strand breaks, is characterised by a massive change in the post-translational …
double strand breaks, is characterised by a massive change in the post-translational …
Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components
M Kanke, Y Kodama, TS Takahashi, T Nakagawa… - The EMBO …, 2012 - embopress.org
The CMG complex composed of Mcm2‐7, Cdc45 and GINS is postulated to be the
eukaryotic replicative DNA helicase, whose activation requires sequential recruitment of …
eukaryotic replicative DNA helicase, whose activation requires sequential recruitment of …
Identification of a heteromeric complex that promotes DNA replication origin firing in human cells
D Boos, M Yekezare, JFX Diffley - Science, 2013 - science.org
Treslin/TICRR (TopBP1-interacting, replication stimulating protein/TopBP1-interacting,
checkpoint, and replication regulator), the human ortholog of the yeast Sld3 protein, is an …
checkpoint, and replication regulator), the human ortholog of the yeast Sld3 protein, is an …
Activation of the replicative DNA helicase: breaking up is hard to do
D Boos, J Frigola, JFX Diffley - Current opinion in cell biology, 2012 - Elsevier
The precise duplication of the eukaryotic genome is accomplished by carefully coordinating
the loading and activation of the replicative DNA helicase so that each replication origin is …
the loading and activation of the replicative DNA helicase so that each replication origin is …