Introduction Wnt/β-catenin signaling is an evolutionarily conserved pathway having a crucial
role in embryonic and adult life. Specifically, the Wnt/β-catenin axis is pivotal to the …

Background: Plants and their derived natural compounds possess various biological and
therapeutic properties, which turns them into an increasing topic of interest and research …

Background: Doxorubicin (DOX), a broad-spectrum chemotherapy drug, has life-threatening
cardiotoxicity. Therefore, searching cardioprotective drugs for DOX-induced cardiotoxicity …

Abstract Alzheimer's disease (AD), a chronic, progressive, neurodegenerative disorder, is
the most common type of dementia. Beta amyloid (Aβ) peptide aggregation and …

Lewy bodies are characteristic spherical inclusions in Parkinson's disease (PD) that are
formed by α-synuclein fibrils. Ferruginol (Fer) is an amonomeric compound isolated from a …

Abstract Vanderbylia robiniophila (Murrill) BK (Huaier) is a kind of higher fungal fruiting body
that is parasitic on the trunk of Sophora japonica and Robinia pseudoacacia L.. As a …

In this short article, the chemistry, sources, contents, pharmacological properties and patents
of ferruginol (FG) and sugiol (SG) are reviewed for the first time. Sources of information cited …

目的利用基于网络细胞反应印记整合文库(LINCS) 提供的药物扰动基因表达谱数据和阿尔茨海
默病(AD) 谷氨酸毒性发病机制, 以囊泡谷氨酸转运体1 (VGLUT1) 为靶点进行抗AD …

Jatrophone (JAT) is a macrocyclic diterpene isolated from several Jatropha and Euphorbia
species. Jatrophone and jatrophane derivatives are of wide interest because of their diverse …

Dementia has emerged as one of the main threats to human health in the modern
civilization. Increased aging of world population and unhealthy lifestyle habits have been …