Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

Cytosolic innate immune sensors are critical for host defense and form complexes, such as
inflammasomes and PANoptosomes, that induce inflammatory cell death. The sensor …

COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …

Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for
immune activation, but also induce immune-suppressive feedback circuits that impede …

Chromatin modifications are crucial for development, yet little is known about their dynamics
during differentiation. Hematopoiesis provides a well-defined model to study chromatin state …

Introduction Many genetic variants associated with common disease susceptibility occur
close to immune-related genes in noncoding DNA, suggestive of a regulatory function. The …

Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …

▪ Abstract The phytohemagglutinin-induced virus-inhibitor may, however, be produced in
white cells in response to a stimulation of cellular RNA synthesis and may be a feedback …

Interferons play key roles in mediating antiviral and antigrowth responses and in modulating
immune response. The main signaling pathways are rapid and direct. They involve tyrosine …