Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …

Methamphetamine (METH) is an illicit psychostimulant that is abused throughout the world.
METH addiction is also a major public health concern and the abuse of large doses of the …

Neurons are known to rely on autophagy for removal of defective proteins or organelles to
maintain synaptic neurotransmission and counteract neurodegeneration. In spite of its …

Actin cytoskeleton dynamics play vital roles in most forms of intracellular trafficking by
promoting the biogenesis and transport of vesicular cargoes. Mounting evidence indicates …

The central functions fulfilled by mitochondria as both energy generators essential for tissue
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …

Autophagy refers to a ubiquitous set of catabolic pathways required to achieve proper
cellular homeostasis. Aberrant autophagy has been implicated in a multitude of diseases …

Parkinson's disease (PD) that afflicts millions of individuals worldwide is associated with
deposits of aggregate-prone proteins (eg, α-synuclein) and with mitochondrial dysfunction in …

Autophagy, the cellular process responsible for degradation and recycling of cytoplasmic
components through the autophagosomal–lysosomal pathway, is fundamental for neuronal …

Highlights•Autophagy is a lysosomal degradation process essential for neuronal
survival.•Autophagy is a highly compartmentalized process in neurons.•Intercellular …

Synapses must be preserved throughout an organism's lifespan to allow for normal brain
function and behavior. Synapse maintenance is challenging given the long distances …