Astrocyte biomarkers in Alzheimer's disease

SF Carter, K Herholz, P Rosa-Neto, L Pellerin… - Trends in molecular …, 2019 - cell.com
Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely
overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an …

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

EM Hol, M Pekny - Current opinion in cell biology, 2015 - Elsevier
Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as
nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system …

Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease

P Chatterjee, S Pedrini, E Stoops, K Goozee… - Translational …, 2021 - nature.com
Glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, can be measured in
blood samples, and has been associated with Alzheimer's disease (AD). However, plasma …

Astrocyte reactivity and reactive astrogliosis: costs and benefits

M Pekny, M Pekna - Physiological reviews, 2014 - journals.physiology.org
Astrocytes are the most abundant cells in the central nervous system (CNS) that provide
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …

Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain

V Karri, M Schuhmacher, V Kumar - Environmental toxicology and …, 2016 - Elsevier
Human exposure to toxic heavy metals is a global challenge. Concurrent exposure of heavy
metals, such as lead (Pb), cadmium (Cd), arsenic (As) and methylmercury (MeHg) are …

Effects of neurotrophic factors in glial cells in the central nervous system: expression and properties in neurodegeneration and injury

S Pöyhönen, S Er, A Domanskyi… - Frontiers in physiology, 2019 - frontiersin.org
Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

GFAP in health and disease

J Middeldorp, EM Hol - Progress in neurobiology, 2011 - Elsevier
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

[HTML][HTML] Reactive gliosis in the pathogenesis of CNS diseases

M Pekny, M Pekna - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Astrocytes maintain the homeostasis of the central nervous system (CNS) by eg recycling of
neurotransmitters and providing nutrients to neurons. Astrocytes function also as key …

Glial fibrillary acidic protein: GFAP-thirty-one years (1969–2000)

LF Eng, RS Ghirnikar, YL Lee - Neurochemical research, 2000 - Springer
It is now well established that the glial fibrillary acidic protein (GFAP) is the principal 8–9 nm
intermediate filament in mature astrocytes of the central nervous system (CNS). Over a …

Astrocyte activation and reactive gliosis

M Pekny, M Nilsson - Glia, 2005 - Wiley Online Library
Astrocytes become activated (reactive) in response to many CNS pathologies, such as
stroke, trauma, growth of a tumor, or neurodegenerative disease. The process of astrocyte …