Mechanical forces direct stem cell behaviour in development and regeneration
Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …
Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration
MÁ Brennan, P Layrolle… - Advanced functional …, 2020 - Wiley Online Library
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …
Hyaluronic acid hydrogels for biomedical applications
JA Burdick, GD Prestwich - Advanced materials, 2011 - Wiley Online Library
Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human
body, is crucial for many cellular and tissue functions and has been in clinical use for over …
body, is crucial for many cellular and tissue functions and has been in clinical use for over …
Macroscale biomaterials strategies for local immunomodulation
The immune system plays key roles in tissue homeostatic and disease processes, and
manipulation of innate and adaptive immune responses is of great promise for a wide array …
manipulation of innate and adaptive immune responses is of great promise for a wide array …
[HTML][HTML] Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease
The broad repertoire of secreted trophic and immunomodulatory cytokines produced by
mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has …
mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has …
[HTML][HTML] Biomaterial-induced pathway modulation for bone regeneration
Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …
Physical cues of biomaterials guide stem cell differentiation fate
Millions of people lose or damage their organs or tissues due to disease, birth defects, or
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …
Substrate stiffness controls osteoblastic and chondrocytic differentiation of mesenchymal stem cells without exogenous stimuli
R Olivares-Navarrete, EM Lee, K Smith, SL Hyzy… - PloS one, 2017 - journals.plos.org
Stem cell fate has been linked to the mechanical properties of their underlying substrate,
affecting mechanoreceptors and ultimately leading to downstream biological response …
affecting mechanoreceptors and ultimately leading to downstream biological response …
Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?
AH Klopp, A Gupta, E Spaeth, M Andreeff… - Stem cells, 2011 - academic.oup.com
The discovery that mesenchymal stem cells (MSCs) are recruited into tumors has led to a
great deal of interest over the past decade in the function of MSCs in tumors. To address …
great deal of interest over the past decade in the function of MSCs in tumors. To address …
Large-scale production of stem cells utilizing microcarriers: a biomaterials engineering perspective from academic research to commercialized products
Human stem cells, including pluripotent, embryonic and mesenchymal, stem cells play
pivotal roles in cell-based therapies. Over the past decades, various methods for expansion …
pivotal roles in cell-based therapies. Over the past decades, various methods for expansion …