β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …

T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …

Much of the mechanism by which Wnt signaling drives proliferation during oncogenesis is
attributed to its regulation of the cell cycle. Here, we show how Wnt/β‐catenin signaling …

Gastric cancer (GC) is the most common gastrointestinal malignant tumor, and distant
metastasis is a critical factor in the prognosis of patients with GC. Understanding the …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent …

Wnt proteins comprise a large family of highly conserved glycoproteins known for their role
in development, cell fate specification, tissue regeneration, and tissue homeostasis …

One of the early surprises in the study of cell adhesion was the discovery that β-catenin
plays dual roles, serving as an essential component of cadherin-based cell–cell adherens …

T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) proteins (TCFs) from the High
Mobility Group (HMG) box family act as the main downstream effectors of the Wnt signaling …

Active canonical Wnt signaling results in recruitment of β‐catenin to DNA by TCF/LEF family
members, leading to transcriptional activation of TCF target genes. However, additional …

Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt
ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via …