Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice

C Li, H Zhao, L Cheng, B Wang - Cell & Bioscience, 2021 - Springer
Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment
of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from …

Mesenchymal stem cells and immunomodulation: current status and future prospects

F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Mesenchymal stem cells: a new trend for cell therapy

X Wei, X Yang, Z Han, F Qu, L Shao… - Acta Pharmacologica …, 2013 - nature.com
Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in
the clinic for approximately 10 years. From animal models to clinical trials, MSCs have …

Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications

ME Castro-Manrreza… - Journal of immunology …, 2015 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiation into
mesenchymal lineages and that can be isolated from various tissues and easily cultivated in …

Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells

M Strioga, S Viswanathan, A Darinskas… - Stem cells and …, 2012 - liebertpub.com
Mesenchymal stem/stromal cells (MSCs) comprise a heterogeneous population of cells with
multilineage differentiation potential, the ability to modulate oxidative stress, and secrete …

Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells

P Luz-Crawford, M Kurte, J Bravo-Alegría… - Stem cell research & …, 2013 - Springer
Abstract Introduction Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with
immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit …

Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

MB Murphy, K Moncivais, AI Caplan - Experimental & molecular …, 2013 - nature.com
Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into
tissues including bone, cartilage and adipose in vitro, but it is their trophic, paracrine and …

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

P Connick, M Kolappan, C Crawley… - The Lancet …, 2012 - thelancet.com
Background More than half of patients with multiple sclerosis have progressive disease
characterised by accumulating disability. The absence of treatments for progressive multiple …

Mesenchymal stem cell effects on T-cell effector pathways

MM Duffy, T Ritter, R Ceredig, MD Griffin - Stem cell research & therapy, 2011 - Springer
Mesenchymal stem (stromal) cells (MSCs) are rare, multipotent progenitor cells that can be
isolated and expanded from bone marrow and other tissues. Strikingly, MSCs modulate the …