Castration-resistant prostate cancer (CRPC), especially metastatic castration-resistant
prostate cancer (mCRPC) is one of the most prevalent malignancies and main cause of …

The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Newly growing evidence highlights the essential role that epitranscriptomic marks play in the
development of many cancers; however, little is known about the role and implications of …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Recently, feature selection and dimensionality reduction have become fundamental tools for
many data mining tasks, especially for processing high-dimensional data such as gene …

For the positron emission tomography (PET) imaging of prostate cancer, radiotracers
targeting the prostate-specific membrane antigen (PSMA) are nowadays used in clinical …

Cancer-associated genetic alterations induce expression of tumour antigens that can
activate CD8+ cytotoxic T cells (CTLs), but the microenvironment of established tumours …

Extremely rare circulating tumor cell (CTC) clusters are both increasingly appreciated as
highly metastatic precursors and virtually unexplored. Technologies are primarily designed …

The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that
drives prostate cancer progression. Some prostate cancers escape androgen dependence …

Background Prostate tumor heterogeneity and biopsy undersampling pose challenges to
accurate, individualized risk assessment for men with localized disease. Objective To …