Many synthetic biology applications rely on programming living cells using gene circuits–the
assembly and wiring of genetic elements to control cellular behaviors. Extensive progress …

Regulation of future RNA and protein numbers is a key process by which cells continuously
best fit the environment. In bacteria, RNA and proteins exist in small numbers and their …

How the noisy expression of regulatory proteins affects timing of intracellular events is an
intriguing fundamental problem that influences diverse cellular processes. Here we use the …

Timely progression of a genetic program is critical for embryonic development. However,
gene expression involves inevitable fluctuations in biochemical reactions leading to …

Noise-induced heterogeneity in gene expression is an inherent reality for cells. However, it
is not well understood how noise strength changes for a single gene while the host cell is …

The accumulation of protein damage is one of the major drivers of replicative ageing,
describing a cell's reduced ability to reproduce over time even under optimal conditions …

Background Double-strand break repair (DSBR) is a highly regulated process involving
dozens of proteins acting in a defined order to repair a DNA lesion that is fatal for any living …

Aging is a complex phenomenon of functional decay in a biological organism. Although the
effects of aging are readily recognizable in a wide range of organisms, the cause (s) of aging …

Cells must continuously adjust to changing environments and, thus, have evolved
mechanisms allowing them to respond to repeated stimuli. While faster gene induction upon …

There is a special node, which the large noise of the upstream element may not always lead
to a broad distribution of downstream elements. This node is DNA, with upstream element …