Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms
Nitric oxide (NO) is an important vasodilator with a well-established role in cardiovascular
homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and …
homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and …
[HTML][HTML] Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases
Nitric oxide (NO) is a vasoactive substance synthesized from l-arginine by neuronal (NOS1),
endothelial (NOS3), and inducible (NOS2) nitric oxide synthases. NOS3 is the most …
endothelial (NOS3), and inducible (NOS2) nitric oxide synthases. NOS3 is the most …
Nitric oxide formation is inversely related to serum levels of antiangiogenic factors soluble fms-like tyrosine kinase-1 and soluble endogline in preeclampsia
Deficient NO formation has been implicated in hypertensive disorders of pregnancy.
However, no previous study has compared the circulating nitrite concentrations in healthy …
However, no previous study has compared the circulating nitrite concentrations in healthy …
Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins?
P Balakumar, S Kathuria, G Taneja, S Kalra… - Journal of molecular and …, 2012 - Elsevier
Statins are widely used in the treatment of dyslipidemia and associated cardiovascular
abnormalities including atherosclerosis, hypertension and coronary heart disease. Needless …
abnormalities including atherosclerosis, hypertension and coronary heart disease. Needless …
Effects of statins on matrix metalloproteinases and their endogenous inhibitors in human endothelial cells
TC Izidoro-Toledo, DA Guimaraes, VA Belo… - Naunyn-Schmiedeberg's …, 2011 - Springer
Statins exert anti-inflammatory effects and downregulate matrix metalloproteinases (MMPs)
expression, thus contributing to restore cardiovascular homeostasis in cardiovascular …
expression, thus contributing to restore cardiovascular homeostasis in cardiovascular …
Modulation of nitric oxide formation by endothelial nitric oxide synthase gene haplotypes
Nitric oxide (NO) is a major regulator of the cardiovascular system. However, the effects of
endothelial nitric oxide synthase (eNOS) gene polymorphisms or haplotypes on the …
endothelial nitric oxide synthase (eNOS) gene polymorphisms or haplotypes on the …
The role of genetics in pre-eclampsia and potential pharmacogenomic interventions
PJ Williams, L Morgan - Pharmacogenomics and personalized …, 2012 - Taylor & Francis
The pregnancy-specific condition pre-eclampsia not only affects the health of mother and
baby during pregnancy but also has long-term consequences, increasing the chances of …
baby during pregnancy but also has long-term consequences, increasing the chances of …
The endothelial nitric oxide synthase− 786 T> C polymorphism and the exercise-induced blood pressure and nitric oxide responses among men with elevated blood …
AL Augeri, GJ Tsongalis, JL Van Heest, CM Maresh… - Atherosclerosis, 2009 - Elsevier
OBJECTIVE: A polymorphism (− 786 T> C) in the promoter region of the endothelial nitric
oxide synthase gene (eNOS) has important functional characteristics. We examined the …
oxide synthase gene (eNOS) has important functional characteristics. We examined the …
Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome
VA Gomes, A Casella-Filho, ACP Chagas… - Nitric Oxide, 2008 - Elsevier
Metabolic syndrome (MetS) denotes a clustering of risk factors that may affect nitric oxide
(NO) bioavailability and predispose to cardiovascular diseases, which are delayed by …
(NO) bioavailability and predispose to cardiovascular diseases, which are delayed by …
eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension
Variations of the endothelial nitric oxide synthase (eNOS) gene have been associated with
hypertensive disorders of pregnancy. We examined whether eNOS polymorphisms affect the …
hypertensive disorders of pregnancy. We examined whether eNOS polymorphisms affect the …