While it is true that pharmacotherapy has achieved desired health outcomes, significant
unmet medical needs persist in the field of central nervous system (CNS) drugs, particularly …

About 30% of all small molecular drugs are organic cations (OCs). If these are more or less
hydrophilic, they require membrane transporters to pass through biological membranes …

Organic cations comprise a significant part of medically relevant drugs and endogenous
substances. Such substances need organic cation transporters for efficient transfer via cell …

Many organic cations (OCs) may be transported through membranes by a genetically still
uncharacterized proton-organic cation (H+ OC) antiporter. Here, we characterized an …

A drug/proton-antiporter, whose the molecular structure is still unknown, was previously
evidenced at the blood-brain barrier (BBB) by functional experiments. The computational …

Psychedelics have recently re‐emerged as potential treatments for various psychiatric
conditions that impose major public health costs and for which current treatment options …

The pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter system facilitates
the active net uptake of several marketed organic cationic drugs across the blood-brain …

Solute carriers (SLCs) are membrane transporters that import and export a range of
endogenous and exogenous substrates, including ions, nutrients, metabolites …

'Drug abuse'has been recognized as one of the most pressing epidemics in contemporary
society. Traditional research has primarily focused on understanding how drugs induce …

Most central nervous system (CNS) active drugs are organic cations, which need carrier
proteins for efficient transfer through the blood–brain barrier (BBB). A genetically still …