Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

Neuroimmunology and immunometabolism are burgeoning topics of study, but the
intersection of these two fields is scarcely considered. This interplay is particularly prevalent …

The hyperphagia, low sympathetic nervous system tone, and decreased circulating
concentrations of bioactive thyroid hormones that are common to states of congenital leptin …

Leptin, the long-sought satiety factor of adipocytes origin, has emerged as one of the major
signals that relay the status of fat stores to the hypothalamus and plays a significant role in …

Appetite regulation is part of a feedback system that controls the energy balance, involving a
complex interplay of hunger and satiety signals, produced in the hypothalamus as well as in …

Kisspeptin stimulates reproduction, and kisspeptin cells in the arcuate nucleus (ARC)
express Ob-Rb in the mouse. Herein we report studies in ewes to determine whether …

Background: Stress affects body weight and food intake, but the underlying mechanisms are
not well understood. Methods: We evaluated the changes in body weight and food intake of …

The neuropeptide Y (NPY)/Agouti-related protein (AgRP) neurons of the hypothalamic
arcuate nucleus are thought to promote feeding. Here, we demonstrate that feeding state in …

Health problems resulting from obesity could offset many of the recent health gains achieved
by modern medicine, and obesity may replace tobacco as the number one health risk for …

Neuropeptide Y (NPY) is one the most potent orexigenic peptides found in the brain. It
stimulates food intake with a preferential effect on carbohydrate intake. It decreases latency …