Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

Astrocytes participate in all essential CNS functions, including blood flow regulation, energy
metabolism, ion and water homeostasis, immune defence, neurotransmission, and adult …

In this study, we investigated whether intrinsic glial dysfunction contributes to the
pathogenesis of schizophrenia (SCZ). Our approach was to establish humanized glial …

Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple
sclerosis. To improve our understanding of human oligodendrocyte development, which …

The concept of adaptive myelination—myelin plasticity regulated by activity—is an important
advance for the field. What signals set up the adaptable pattern in the first place? Here we …

Astrocytes are now viewed as key elements of brain wiring as well as neuronal
communication. Indeed, they not only bridge the gap between metabolic supplies by blood …

Neonatally transplanted human glial progenitor cells (hGPCs) densely engraft and
myelinate the hypomyelinated shiverer mouse. We found that, in hGPC-xenografted mice …

Oligodendroglial pathology is central to de‐and dysmyelinating, but also contributes to
neurodegenerative and psychiatric diseases as well as brain injury. The understanding of …

Loss of 5‐hydroxymethylcytosine (5hmC) has been associated with mutations of the ten–
eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild …

Human oligodendrocyte progenitor cell (OPC) specification and differentiation occurs slowly
and limits the potential for cell-based treatment of demyelinating disease. In this study, using …