While licensed vaccines elicit protective antibody responses against a variety of viral
infections, an effective vaccine for hepatitis C virus (HCV) has remained elusive. The …

The introduction of direct-acting antivirals (DAAs) has revolutionized hepatitis C treatment.
Short courses of treatment with these drugs are highly beneficial to patients, eliminating …

Many serious bacterial infections are antibiotic refractory due to biofilm formation. A key
structural component of biofilm is extracellular DNA, which is stabilized by bacterial proteins …

Hepatitis C virus (HCV) is one of very few viruses that are either naturally cleared, or
alternatively persist to cause chronic disease. Viral diversity and escape, as well as host …

Scavenger receptors (SR) are not only pattern recognition receptors involved in the immune
response against pathogens but are also important receptors exploited by different virus to …

Extraordinary genetic diversity is a hallmark of hepatitis C virus (HCV). Therefore, accurate
measurement of the breadth of antibody neutralizing activity across diverse HCV isolates is …

The global health burden for hepatitis C virus (HCV) remains high, despite available
effective treatments. To eliminate HCV, a prophylactic vaccine is needed. One major …

Introduction Comprehensive investigation of the within-host evolution of hepatitis C virus
(HCV) variants has been difficult without high coverage deep sequencing data and …

Objective Despite of antiviral drugs and successful treatment, an effective vaccine against
hepatitis C virus (HCV) infection is still required. Recently, bioinformatic methods same as …

RNA viruses such as influenza, dengue, SARS, Ebola and yellow fever are a formidable
threat to human health and global economy. They have small genomes, but due to the lack …