Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …

Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single point
mutation in the β-globin gene. As a consequence, deoxygenated hemoglobin polymerizes …

Advanced mitochondrial multi-omics indicate a multi-facet involvement of mitochondria in
the physiology of the cell, changing the perception of mitochondria from being just the …

Sickle cell disease (SCD) is the most severe monogenic hemoglobinopathy caused by a
single genetic mutation that leads to repeated polymerization and depolymerization of …

Sickle cell disease is an inherited hemoglobinopathy leading to the synthesis of hemoglobin
S. Hemoglobin S results in the formation of abnormal sickle-shaped erythrocytes that lead to …

Sickle cell disease (SCD) is an inherited hemoglobinopathy affecting approximately 100,000
individuals in the United States. Cerebrovascular disease is among the most common and …

Hypoxia and hemoglobin S polymerization are two triggers responsible for initiating
erythrocyte sickling and the consequent clinical sickle cell anemia (SCA) events. The …

Overt stroke in adults with sickle cell anemia (SCA) continues to be a major cause of
morbidity and mortality, while no evidence-based strategy for prevention has been reached …

Background Oxidative stress plays a pivotal role in the pathophysiology of sickle cell
disease (SCD) and its associated disease complications. Superoxide Dismutases (SODs) …

Sickle cell disease (SCD) is a hereditary condition caused by a mutation in the β-globin
gene, which replaces glutamic acid with valine in the β-chain of hemoglobin. SCD displays …