Roadmap: proton therapy physics and biology

H Paganetti, C Beltran, S Both, L Dong… - Physics in Medicine …, 2021 - iopscience.iop.org
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

Real-time intrafraction motion monitoring in external beam radiotherapy

J Bertholet, A Knopf, B Eiben… - Physics in medicine …, 2019 - iopscience.iop.org
Radiotherapy (RT) aims to deliver a spatially conformal dose of radiation to tumours while
maximizing the dose sparing to healthy tissues. However, the internal patient anatomy is …

A critical review of radiation therapy: from particle beam therapy (proton, carbon, and BNCT) to beyond

Y Matsumoto, N Fukumitsu, H Ishikawa… - Journal of personalized …, 2021 - mdpi.com
In this paper, we discuss the role of particle therapy—a novel radiation therapy (RT) that has
shown rapid progress and widespread use in recent years—in multidisciplinary treatment …

Dosimetric commissioning and quality assurance of scanned ion beams at the Italian National Center for Oncological Hadrontherapy

A Mirandola, S Molinelli, G Vilches Freixas… - Medical …, 2015 - Wiley Online Library
Purpose: To describe the dosimetric commissioning and quality assurance (QA) of the
actively scanned proton and carbon ion beams at the Italian National Center for Oncological …

Current state and future applications of radiological image guidance for particle therapy

G Landry, C Hua - Medical Physics, 2018 - Wiley Online Library
In this review paper, we first give a short overview of radiological image guidance in photon
radiotherapy, placing emphasis on the fact that linac based radiotherapy has outpaced …

[HTML][HTML] Deformable image registration uncertainty for inter-fractional dose accumulation of lung cancer proton therapy

L Nenoff, CO Ribeiro, M Matter, L Hafner… - Radiotherapy and …, 2020 - Elsevier
Background and purpose Non-small cell lung cancer (NSCLC) patients show typically large
anatomical changes during treatment, making recalculation or adaption necessary. For …

[HTML][HTML] A survey of practice patterns for adaptive particle therapy for interfractional changes

P Trnkova, Y Zhang, T Toshito, B Heijmen… - Physics and imaging in …, 2023 - Elsevier
Background and purpose Anatomical changes may compromise the planned target
coverage and organs-at-risk dose in particle therapy. This study reports on the practice …

Considerations for shoot-through FLASH proton therapy

F Verhaegen, RG Wanders, C Wolfs… - Physics in medicine & …, 2021 - iopscience.iop.org
Purpose. To discuss several pertinent issues related to shoot-through FLASH proton therapy
based on an illustrative case. Methods. We argue that with the advent of FLASH proton …

Comprehensive analysis of proton range uncertainties related to stopping-power-ratio estimation using dual-energy CT imaging

B Li, HC Lee, X Duan, C Shen, L Zhou… - Physics in Medicine & …, 2017 - iopscience.iop.org
The dual-energy CT-based (DECT) approach holds promise in reducing the overall
uncertainty in proton stopping-power-ratio (SPR) estimation as compared to the …

AAPM Task Group Report 290: Respiratory motion management for particle therapy

H Li, L Dong, C Bert, J Chang, S Flampouri… - Medical …, 2022 - Wiley Online Library
Dose uncertainty induced by respiratory motion remains a major concern for treating
thoracic and abdominal lesions using particle beams. This Task Group report reviews the …