Simple Summary Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-
cancer drugs, with twelve agents in current clinical use. Despite recent successes, many …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in
tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe …

The 2017 consensus report of the Asia Dry Eye Society (ADES) on the definition and
diagnosis of dry eyes described dry eye disease as “Dry eye is a multifactorial disease …

Highlights•Albeit their clinical success, ADCs have a relatively narrow therapeutic
index.•Dose-limiting toxicities of ADCs are frequently unrelated to the targeted …

The lipid layer is an essential component of the tear film, providing a smooth optical surface
for the cornea and retarding evaporation from the eye. The meibomian lipids which compose …

Goblet cells within the conjunctival epithelium are specialized cells that secrete mucins onto
the surface of the eye. Recent research has demonstrated new characteristics of the cells …