Emerging functions of the EGFR in cancer
S Sigismund, D Avanzato, L Lanzetti - Molecular oncology, 2018 - Wiley Online Library
The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …
Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
Mechanisms of receptor tyrosine kinase activation in cancer
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors
KD Wegner, N Hildebrandt - Chemical Society Reviews, 2015 - pubs.rsc.org
Semiconductor quantum dots (QDs) have become important fluorescent probes for in vitro
and in vivo bioimaging research. Their nanoparticle surfaces for versatile bioconjugation …
and in vivo bioimaging research. Their nanoparticle surfaces for versatile bioconjugation …
The ErbB/HER family of protein-tyrosine kinases and cancer
R Roskoski Jr - Pharmacological research, 2014 - Elsevier
The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
[HTML][HTML] The Fluid—Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than …
GL Nicolson - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
Abstract In 1972 the Fluid—Mosaic Membrane Model of membrane structure was proposed
based on thermodynamic principals of organization of membrane lipids and proteins and …
based on thermodynamic principals of organization of membrane lipids and proteins and …
EGF receptor trafficking: consequences for signaling and cancer
A Tomas, CE Futter, ER Eden - Trends in cell biology, 2014 - cell.com
The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
The EGFR family: not so prototypical receptor tyrosine kinases
MA Lemmon, J Schlessinger… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
The epidermal growth factor receptor (EGFR) was among the first receptor tyrosine kinases
(RTKs) for which ligand binding was studied and for which the importance of ligand-induced …
(RTKs) for which ligand binding was studied and for which the importance of ligand-induced …
Balancing forces: architectural control of mechanotransduction
CC DuFort, MJ Paszek, VM Weaver - Nature reviews Molecular cell …, 2011 - nature.com
All cells exist within the context of a three-dimensional microenvironment in which they are
exposed to mechanical and physical cues. These cues can be disrupted through …
exposed to mechanical and physical cues. These cues can be disrupted through …
Structure and dynamics of the EGFR/HER2 heterodimer
X Bai, P Sun, X Wang, C Long, S Liao, S Dang… - Cell Discovery, 2023 - nature.com
HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. Its
overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 …
overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 …