Glomerulonephritis: immunopathogenesis and immunotherapy

HJ Anders, AR Kitching, N Leung… - Nature Reviews …, 2023 - nature.com
Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …

Membranous nephropathy: new pathogenic mechanisms and their clinical implications

E Hoxha, L Reinhard, RAK Stahl - Nature Reviews Nephrology, 2022 - nature.com
Membranous nephropathy (MN) is characterized histomorphologically by the presence of
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …

Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry

TN Caza, AJ Storey, SI Hassen, C Herzog… - Kidney international, 2023 - Elsevier
Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-
based proteomics. However, antigenic targets of disease are unknown for over 10% of …

[HTML][HTML] COVID-19 and glomerular diseases

N Klomjit, L Zand, LD Cornell, MP Alexander - Kidney International Reports, 2023 - Elsevier
COVID-19 is a systemic disease, and the kidney is one of the target organs of infection.
Kidney injury is common and can occur in up to 40% of patients. Several glomerular …

Netrin G1 is a novel target antigen in primary membranous nephropathy

L Reinhard, M Machalitza, T Wiech… - Journal of the …, 2022 - journals.lww.com
Background Primary membranous nephropathy (MN) is caused by circulating
autoantibodies binding to antigens on the podocyte surface. PLA 2 R1 is the main target …

Mapping antigens of membranous nephropathy: almost there

S Sethi, B Madden - Kidney international, 2023 - Elsevier
Membranous nephropathy (MN) is characterized by subepithelial accumulation of immune
complexes along the glomerular basement membranes. The immune complexes …

Novel antigens and clinical updates in membranous nephropathy

R Avasare, N Andeen, L Beck - Annual review of medicine, 2024 - annualreviews.org
Membranous nephropathy (MN), an autoimmune kidney disease and leading cause of
nephrotic syndrome, leads to kidney failure in up to one-third of affected individuals. Most …

[HTML][HTML] Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use

S Sethi, MC Moura, B Madden, H Debiec, SH Nasr… - Kidney international, 2023 - Elsevier
Drugs are an important secondary cause of membranous nephropathy (MN) with the most
common drugs associated with MN being nonsteroidal anti-inflammatory drugs (NSAIDs) …

Future landscape for the management of membranous nephropathy

F Caravaca-Fontán, F Yandian… - Clinical Kidney …, 2023 - academic.oup.com
Among all glomerular diseases, membranous nephropathy (MN) is perhaps the one in
which major progress has been made in recent decades, in both the understanding of the …

From patterns to proteins: mass spectrometry comes of age in glomerular disease

S Sethi, JD Theis, LMP Palma… - Journal of the American …, 2024 - journals.lww.com
Laser capture microdissection and mass spectrometry (LCM/MS) is a technique that involves
dissection of glomeruli from paraffin-embedded biopsy tissue, followed by digestion of the …