Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Epigenetic and epitranscriptomic modifications that regulate physiological processes of an
organism at the DNA and RNA levels, respectively, are novel therapeutic candidates for …

Epigenetic modifications have been identified as critical molecular determinants influencing
macrophage plasticity and heterogeneity. Among these, histone lactylation is a recently …

We previously showed that knockdown or deletion of Fos downstream transcript (FosDT; a
stroke-induced brain-specific long noncoding RNA) is neuroprotective. We presently tested …

Aims Remote ischemic pre‐conditioning (RIPC) protects against ischemia/reperfusion (I/R)
injury. However, the mechanisms underlying this protection remain unclear. In the present …

Post‐stroke neuroinflammation is pivotal in brain repair, yet persistent inflammation can
aggravate ischemic brain damage and hamper recovery. Following stroke, specific …

The role of chromatin biology and epigenetics in disease progression is gaining increasing
recognition. Genes that escape X chromosome inactivation (XCI) can impact …

Autosomal dominant polycystic kidney disease (ADPKD) is the fourth leading cause of end-
stage renal disease, contributing substantially to patient morbidity, mortality, and healthcare …

Several historic, scientific events have occurred in the decade 2013–2023, in particular the
COVID-19 pandemic. This massive pathogenic threat, which has affected the world's …

ABSTRACT Background Globally, individuals of African ancestry have a relatively greater
stroke preponderance compared to other racial/ethnic groups. The higher prevalence of …