Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases
IJ Yeo, CK Lee, SB Han, J Yun, JT Hong - Pharmacology & therapeutics, 2019 - Elsevier
Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …
A systematic review of asthma case definitions in 67 birth cohort studies
Background Birth cohort studies are a valuable source of information about potential risk
factors for childhood asthma. To better understand similarities and variations in findings …
factors for childhood asthma. To better understand similarities and variations in findings …
YKL-40 mediates airway remodeling in asthma via activating FAK and MAPK signaling pathway
Y Sun, Z Shi, B Liu, XG Li, G Li, F Yang, H Tang - Cell Cycle, 2020 - Taylor & Francis
ABSTRACT YKL-40 is a chitinase-like protein which was significantly elevated in asthma
patients and related closely to asthma severity and airway remodeling. Airway remodeling in …
patients and related closely to asthma severity and airway remodeling. Airway remodeling in …
Genetic and epigenetic regulation of YKL-40 in childhood
Background Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic
variation in its encoding gene (chitinase 3–like 1 [CHI3L1]) and are increased in patients …
variation in its encoding gene (chitinase 3–like 1 [CHI3L1]) and are increased in patients …
A longitudinal assessment of circulating YKL‐40 levels in preschool children with wheeze
A James, K Stenberg Hammar… - Pediatric Allergy and …, 2017 - Wiley Online Library
Background The chitinase‐like protein YKL‐40 (CHI 3L1) is elevated in the circulation of
adults and schoolchildren with chronic severe asthma. It is unknown whether YKL‐40 is …
adults and schoolchildren with chronic severe asthma. It is unknown whether YKL‐40 is …
Functional variant of CHI3L1 gene is associated with neck metastasis in oral cancer
CW Su, MK Chen, WC Hung, SF Yang… - Clinical Oral …, 2019 - Springer
Objectives Oral cancer is the most common head and neck malignancy, and it is associated
with a high recurrence rate and lymph node metastasis potential. YKL-40, also known as …
with a high recurrence rate and lymph node metastasis potential. YKL-40, also known as …
Chitinase 3‐like 1 polymorphisms and risk of chronic obstructive pulmonary disease and asthma in a Chinese population
T Yu, W Niu, H Niu, R Duan, F Dong… - The Journal of Gene …, 2020 - Wiley Online Library
Abstract Background Chitinase 3‐like 1 (CHI3L1) plays an important role in airway
inflammation and tissue remodeling; however, its pathogenic role in lung diseases remains …
inflammation and tissue remodeling; however, its pathogenic role in lung diseases remains …
Adenovirus vector-mediated YKL-40 shRNA attenuates eosinophil airway inflammation in a murine asthmatic model
L Wang, A Bao, Y Zheng, A Ma, Y Wu, H Shang… - Gene Therapy, 2021 - nature.com
Recent studies have revealed that YKL-40 is involved in the pathogenesis of asthma.
However, its specific mechanism remains unclear. The present study aims to investigate the …
However, its specific mechanism remains unclear. The present study aims to investigate the …
Functional study of the association of CHI3L1 polymorphisms with asthma susceptibility in the Southwest Chinese Han population
G Chen, MM Zhang, Y Wang, SQ Wu… - Bioscience …, 2019 - portlandpress.com
Abstract Background: Chitinase 3-like 1 (CHI3L1) is involved in the Th2 cell mediated
pathway, tissue remodeling and fibrosis. Correlations of CHI3L1 gene polymorphisms with …
pathway, tissue remodeling and fibrosis. Correlations of CHI3L1 gene polymorphisms with …
Investigation of chitinase3like-1 (Chiti3L1) gene polymorphism (rs4950928) with susceptibility to allergic asthma in Iranian Northwestern Azeri population
D Elieh Ali Komi, M Sadeghi-Shabestari… - Research in …, 2019 - rmm.mazums.ac.ir
Background: In addition to cellular and molecular mechanisms involved in the pathogenesis
of asthma, mounting evidences demonstrate that single nucleotide polymorphisms (SNPs) in …
of asthma, mounting evidences demonstrate that single nucleotide polymorphisms (SNPs) in …