The impact of cultivation strategy on the cost of recombinant protein production is crucial for
defining cost-effective bioreactor operation conditions. This paper presents a methodology …

Several studies have searched for new antigens to produce pneumococcal vaccines that are
more effective and could provide broader coverage, given the great number of serotypes …

An unstructured–unsegregated temperature-dependent kinetic model was developed and
validated to describe ethanol fermentation in a mixture of xylose and glucose for the …

The integration of state estimation and control is a promising approach to overcome
challenges related to unavailable or noisy online measurements and plant-model mismatch …

Antibody fragments such as Fab's require the formation of disulfide bonds to achieve a
proper folding state. During their recombinant, periplasmic expression in Escherichia coli …

The Zika Virus (ZIKV) is an emerging arbovirus of great public health concern, particularly in
the Americas after its last outbreak in 2015. There are still major challenges regarding …

In the biopharmaceutical industry, accurate prediction of the oxygen uptake rate (OUR) is
critical to understanding cell health, where OUR is related to the oxygen transfer rate (OTR) …

Background Determination of the volumetric oxygen transfer coefficient (kLa) plays an
important role in the design and characterization of bioreactors. Among all methods …

Liquid culture and solid culture fermentation are widely used to produce a range of
metabolites. Despite the use of solid culture fermentation in some cases, most fermentations …

Escherichia coli (E. coli) is the most common host for recombinant protein production. A high
cell density culture (HCDC) of E. coli is regarding be an efficient way to improve recombinant …