Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

Maternal adiposity deleteriously affects obstetrical health and has been associated with long-
term adverse consequences in offspring. Here we conducted an umbrella review …

Importance Lower educational attainment is associated with increased risk of adverse
pregnancy outcomes, but it is unclear which pathways mediate this association. Objective To …

Background: Preeclampsia is a leading cause of maternal morbidity, and dyslipidemia has
been associated with preeclampsia in observational studies. We use Mendelian …

BACKGROUND: Preeclampsia is a leading cause of maternal and perinatal morbidity and
mortality. However, the current understanding of its underlying biological pathways remains …

Context Evidence has shown maternal androgen levels in both the general population and
populations with hyperandrogenic disorders are inversely associated with offspring birth …

Aim This study examined sex-based differences in associations of vascular risk factors with
incident cardiovascular events in the UK Biobank. Methods Baseline participant …

The association between maternal preconception blood pressure (BP) and preterm birth
(PTB) is still unclear. The purpose of this study was to investigate the association between …

Objective This study investigates the relationship between hypertension, dysregulation of
the autonomic nervous system, heart rate variability (HRV), and chronic inflammation …

Objective Observational studies show that hypertensive disorders of pregnancy (HDPs) are
related to unfavourable maternal cardiovascular disease (CVD) risk profiles later in life. We …