Iron is an essential element for multiple fundamental biological processes required for life;
yet iron overload can be cytotoxic. Consequently, iron concentrations at the cellular and …

In general, iron represents a double-edged sword in metabolism in most tissues, especially
in the brain. Although the high metabolic demands of brain cells require iron as a redox …

Handling a life‐supporting yet redox‐active metal like iron represents a significant challenge
to cells and organisms that must not only tightly balance intra‐and extracellular iron …

Abstract Mycobacterium tuberculosis (M. tb), the major causative agent of tuberculosis, has
evolved mechanisms to evade host defenses and persist within host cells. Host-directed …

During physiologic stresses, like micronutrient starvation, infection, and cancer, the cytosolic
moonlighting protein glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) is trafficked to …

Rapid clearance of apoptotic cells by phagocytes is crucial for organogenesis, tissue
homeostasis, and resolution of inflammation. This process is initiated by surface exposure of …

Protein aggregate accumulation is a pathological hallmark of several neurodegenerative
disorders. Autophagy is critical for clearance of aggregate-prone proteins. In this study, we …