Effective regeneration of bone defects often presents significant challenges, particularly in
patients with decreased tissue regeneration capacity due to extensive trauma, disease …

Critical size skeletal defects resulting from trauma and pathological disorders still remain a
major clinical problem worldwide. Bone engineering aims at generating unlimited amounts …

Tissue engineering is a promising alternative to autografts or allografts for the regeneration
of large bone defects. Cell-free biomaterials with different degrees of sophistication can be …

In vitro manipulation of human stem cells is a critical process in regenerative medicine and
cellular therapies. Strategies and methods to maintain stem cells and direct them into …

Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a
promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) …

Mesenchymal stem cells (MSC) have been extensively studied over the past years for the
treatment of different diseases. Most of the ongoing clinical trials currently involve the use of …

Regeneration of bone defects is often limited due to compromised bone tissue physiology.
Previous studies suggest that engineered extracellular matrices enhance the regenerative …

Elucidation of the molecular mechanisms that regulate the differentiation of adipose-derived
mesenchymal stem cells into osteogenic cells may lead to new methods for bone tissue …

Polyetheretherketone (PEEK) titanium composite (PTC) is a novel interbody fusion device
that combines a PEEK core with titanium alloy (Ti6Al4V) endplates. The present study aimed …

Nowadays, modern approaches in tissue engineering include the combination of
therapeutic relevant cells with high quality, biocompatible biomaterials. The resulting …