Hereditary ataxia: A focus on heme metabolism and fe-s cluster biogenesis

D Chiabrando, F Bertino, E Tolosano - International Journal of Molecular …, 2020 - mdpi.com
Heme and Fe-S clusters regulate a plethora of essential biological processes ranging from
cellular respiration and cell metabolism to the maintenance of genome integrity. Mutations in …

[HTML][HTML] Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH

DT Jayaram, P Sivaram, P Biswas, Y Dai… - Research …, 2024 - ncbi.nlm.nih.gov
Heme is an iron-containing cofactor essential for life. In eukaryotes heme is generated in the
mitochondria and must leave this organelle to reach protein targets in other cell …

Studien zur Untersuchung der Interaktion von Häm und Hämopexin

MS Detzel - 2023 - bonndoc.ulb.uni-bonn.de
In hämolytischen Zuständen lysieren Erythrocyten, es tritt Hämoglobin aus und dieses setzt
Häm frei. Das Eisenion von Häm kann an Fenton-artigen Reaktionen teilnehmen, die …

[PDF][PDF] Dysregulation of FLVCR1-dependent mitochondrial calcium handling in neural stem cells causes congenital hydrocephalus

F Bertino - 2023 - iris.unito.it
Congenital hydrocephalus (CH), occurring in approximately 1/1000 live births, represents an
important clinical challenge due to the limited knowledge of underlying molecular …