Synthesis and application of trehalose materials

D Vinciguerra, MB Gelb, HD Maynard - JACS Au, 2022 - ACS Publications
Trehalose is a naturally occurring, nonreducing disaccharide that is widely used in the
biopharmaceutical, food, and cosmetic industries due to its stabilizing and cryoprotective …

Modulation of amyloid protein fibrillation by synthetic polymers: Recent advances in the context of neurodegenerative diseases

P Ghosh, P De - ACS Applied Bio Materials, 2020 - ACS Publications
Protein misfolding and aggregation have attracted immense research interests due to their
connection with an array of degenerative diseases including neurodegenerative disorders …

[HTML][HTML] Advances in nanotechnology versus stem cell therapy for the theranostics of Huntington's disease

G Mustafa, D Hassan, M Zeeshan, G Ruiz-Pulido… - Journal of Drug Delivery …, 2023 - Elsevier
Huntington's disease (HD) is a neurological disorder characterized by a reduction in
medium-spiny neurons in the brain. Currently, there is no cure for HD and treatment relies …

Inhibiting protein aggregation by small molecule-based colloidal nanoparticles

K Debnath, AK Sarkar, NR Jana… - Accounts of materials …, 2021 - ACS Publications
Conspectus Protein aggregation is associated with different human diseases such as
Alzheimer's, Huntington's, Parkinson's, diabetes type II, and cataracts. Currently no effective …

[HTML][HTML] Dendrimers in Alzheimer's disease: recent approaches in multi-targeting strategies

C Arbez-Gindre, BR Steele, M Micha-Screttas - Pharmaceutics, 2023 - mdpi.com
Nanomaterials play an increasingly important role in current medicinal practice. As one of
the most significant causes of human mortality, and one that is increasing year by year …

Trehalose-Bearing Carriers to Target Impaired Autophagy and Protein Aggregation Diseases

A Maruf, M Milewska, M Varga… - Journal of Medicinal …, 2023 - ACS Publications
In recent years, trehalose, a natural disaccharide, has attracted growing attention because of
the discovery of its potential to induce autophagy. Trehalose has also been demonstrated to …

From small molecules to synthesized polymers: potential role in combating amyloidogenic disorders

P Ghosh, A Bera, P Bhadury, P De - ACS Chemical Neuroscience, 2021 - ACS Publications
The concept of developing novel anti-amyloid inhibitors in the scientific community has
engrossed remarkable research interests and embraced significant potential to resolve …

[HTML][HTML] Dendrimers as antiamyloid agents

SA Sorokina, ZB Shifrina - Pharmaceutics, 2022 - mdpi.com
Dendrimer–protein conjugates have significant prospects for biological applications. The
complexation changes the biophysical behavior of both proteins and dendrimers. The …

Biophysical Principles Emerging from Experiments on Protein–Protein Association and Aggregation

B Hribar-Lee, M Lukšič - Annual Review of Biophysics, 2023 - annualreviews.org
Protein–protein association and aggregation are fundamental processes that play critical
roles in various biological phenomena, from cellular signaling to disease progression …

Copolymer Polydopamine Nanoparticles as Multifunctional Nanoinhibitors for Modulating β-Amyloid Aggregation

M Jin, B Du, X Liu, W Mei, H Wang… - ACS Applied Nano …, 2022 - ACS Publications
β-Amyloid (Aβ) aggregation is considered to be the pathological feature of Alzheimer's
disease (AD). Metal ions (such as Cu2+, Zn2+, Fe3+, etc.) can accelerate Aβ aggregation …