Mesothelial cells in tissue repair and fibrosis

SE Mutsaers, K Birnie, S Lansley, SE Herrick… - Frontiers in …, 2015 - frontiersin.org
Mesothelial cells are fundamental to the maintenance of serosal integrity and homeostasis
and play a critical role in normal serosal repair following injury. However, when normal …

The pathophysiology of the peritoneal membrane

O Devuyst, PJ Margetts, N Topley - Journal of the American …, 2010 - journals.lww.com
The development of peritoneal dialysis (PD) as a successful therapy has and still depends
on experimental models to test and understand critical pieces of pathophysiology. To date …

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

AT Argaw, L Asp, J Zhang… - The Journal of …, 2012 - Am Soc Clin Investig
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat
clinical relapse are limited, and more selective agents are needed. Disruption of the blood …

Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice

Y Gong, E Hart, A Shchurin… - The Journal of clinical …, 2008 - Am Soc Clin Investig
Inflammation plays a critical role in the development of cardiovascular diseases. Infiltration
of leukocytes to sites of injury requires their exit from the blood and migration across …

Interleukin-1 participates in the progression from liver injury to fibrosis

RG Gieling, K Wallace, YP Han - American Journal of …, 2009 - journals.physiology.org
Interleukin-1 (IL-1) is rapidly expressed in response to tissue damage; however, its role in
coordinating the progression from injury to fibrogenesis is not fully understood. Liver fibrosis …

Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain

CC Ferrari, AM Depino, F Prada, N Muraro… - The American journal of …, 2004 - Elsevier
Interleukin-1β (IL-1) expression is associated with a spectrum of neuroinflammatory
processes related to chronic neurodegenerative diseases. The single-bolus microinjection …

Basic mechanisms and clinical implications of peritoneal fibrosis

PJ Margetts, P Bonniaud - Peritoneal Dialysis International, 2003 - journals.sagepub.com
Fibrosis is a normal response to tissue injury and occurs in diverse clinical settings such as
wound healing, glomerulonephritis, cirrhosis, and pulmonary fibrosis. In wound healing …

Monocyte activation in patients with age-related macular degeneration: a biomarker of risk for choroidal neovascularization?

SW Cousins, DG Espinosa-Heidmann… - Archives of …, 2004 - jamanetwork.com
Objective To evaluate the activation state of macrophage function in patientswith age-related
macular degeneration (AMD) by quantifying the productionof the proinflammatory and …

Oligosaccharides from Polygonatum Cyrtonema Hua: Structural characterization and treatment of LPS-induced peritonitis in mice

L He, B Yan, C Yao, X Chen, L Li, Y Wu, Z Song… - Carbohydrate …, 2021 - Elsevier
Fructooligosaccharide was isolated from Polygonatum Cyrtonema Hua (PFOS) for the first
time. Structure characterized using FT-IR, MALDI-TOF-MS, NMR, AFM, and TEM, indicated …

Pathophysiological changes to the peritoneal membrane during PD‐related peritonitis: the role of mesothelial cells

S Yung, TM Chan - Mediators of inflammation, 2012 - Wiley Online Library
The success of peritoneal dialysis (PD) is dependent on the structural and functional
integrity of the peritoneal membrane. The mesothelium lines the peritoneal membrane and …