Therapeutic DNAzymes: from structure design to clinical applications

J Yan, M Ran, X Shen, H Zhang - Advanced Materials, 2023 - Wiley Online Library
Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their
prosperous gene regulation capability. The efficacy of DNAzymes against many types of …

Recent applications of rolling circle amplification in biosensors and DNA nanotechnology

J Liu, G Xie, S Lv, Q Xiong, H Xu - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Isothermal nucleic acid amplification techniques have emerged as an important diagnostic
tool for clinical applications and food safety inspection. Rolling circle amplification (RCA) is …

Bioorthogonal disassembly of hierarchical DNAzyme nanogel for high-performance intracellular microRNA imaging

J Shang, S Yu, R Li, Y He, Y Wang, F Wang - Nano Letters, 2023 - ACS Publications
Rolling circle amplification (RCA) enables the facile construction of compact and versatile
DNA nanoassemblies which are yet rarely explored for intracellular analysis. This is might …

Dual-Signaling Photoelectrochemical Biosensor Based on Biocatalysis-Induced Vulcanization of Bi2MoO6 Nanosheets

J Xu, R Zeng, L Huang, Z Qiu, D Tang - Analytical Chemistry, 2022 - ACS Publications
A magnetic-assisted photoelectrochemical (PEC) and colorimetric (CL) dual-modal
biosensing platform with high precision was established to monitor prostate-specific antigen …

Isothermal amplifications–a comprehensive review on current methods

J Glökler, TS Lim, J Ida, M Frohme - Critical reviews in biochemistry …, 2021 - Taylor & Francis
The introduction of nucleic acid amplification techniques has revolutionized the field of
medical diagnostics in the last decade. The advent of PCR catalyzed the increasing …

Biomimetic Mineralized CRISPR/Cas RNA Nanoparticles for Efficient Tumor-Specific Multiplex Gene Editing

Y Liang, J Zhang, C Xu, J Wang, W Han, J Yang… - ACS …, 2023 - ACS Publications
CRISPR/Cas9 systems have great potential to achieve sophisticated gene therapy and cell
engineering by editing multiple genomic loci. However, to achieve efficient multiplex gene …

DNA Nanoflower Eye Drops with Antibiotic‐Resistant Gene Regulation Ability for MRSA Keratitis Target Treatment

M Ran, R Sun, J Yan, AT Pulliainen, Y Zhang, H Zhang - Small, 2023 - Wiley Online Library
Methicillin‐resistant Staphylococcus aureus (MRSA) biofilm‐associated bacterial keratitis is
highly intractable, with strong resistance to β‐lactam antibiotics. Inhibiting the MRSA …

DNAzyme nanoconstruct-integrated autonomously-adaptive coatings enhance titanium-implant osteointegration by cooperative angiogenesis and vessel remodeling

M Chen, M Li, X Ren, F Zhou, Y Li, L Tan, Z Luo… - ACS …, 2023 - ACS Publications
Orthopedic implants have a high failure rate due to insufficient interfacial osseointegration,
especially under osteoporotic conditions. Type H vessels are CD31+ EMCN+ capillaries …

Photoswitchable Microgels for dynamic macrophage modulation

Y Kim, R Thangam, J Yoo, J Heo, JY Park… - Advanced …, 2022 - Wiley Online Library
Dynamic manipulation of supramolecular self‐assembled structures is achieved irreversibly
or under non‐physiological conditions, thereby limiting their biomedical, environmental, and …

Aptamer-based biosensing detection for exosomes: from selection to aptasensors

L Zheng, G Yang, I Muhammad, F Qu - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Exosomes reflect their source cells' phenotypic state, making them key biomarkers for
tumors, cardiovascular diseases, neurodegenerative diseases, and immune responses …