Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment

N Samsu - BioMed research international, 2021 - Wiley Online Library
Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease worldwide.
Chronic hyperglycemia and high blood pressure are the main risk factors for the …

Diabetic microvascular disease: an endocrine society scientific statement

EJ Barrett, Z Liu, M Khamaisi, GL King… - The Journal of …, 2017 - academic.oup.com
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Mechanisms of diabetic complications

JM Forbes, ME Cooper - Physiological reviews, 2013 - journals.physiology.org
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

[HTML][HTML] Vascular complications of diabetes: mechanisms of injury and protective factors

C Rask-Madsen, GL King - Cell metabolism, 2013 - cell.com
In patients with diabetes, atherosclerosis is the main reason for impaired life expectancy,
and diabetic nephropathy and retinopathy are the largest contributors to end-stage renal …

Activation of protein kinase C isoforms and its impact on diabetic complications

P Geraldes, GL King - Circulation research, 2010 - Am Heart Assoc
Both cardio-and microvascular complications adversely affect the life quality of patients with
diabetes and have been the leading cause of mortality and morbidity in this population …

Therapeutic potential of curcumin in diabetic complications

N Parsamanesh, M Moossavi, A Bahrami… - Pharmacological …, 2018 - Elsevier
Diabetes mellitus is an extremely prevalent endocrine disease and a major global public
health concern. Diabetic complications, such as retinopathy, nephropathy, neuropathy and …

Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: an update

N Bhattacharjee, S Barma, N Konwar… - European journal of …, 2016 - Elsevier
Diabetic nephropathy (DN), a chronic complication of diabetes, is charecterized by
glomerular hypertrophy, proteinuria, decreased glomerular filtration, and renal fibrosis …

From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy

G Wolf, S Chen, FN Ziyadeh - Diabetes, 2005 - Am Diabetes Assoc
Nephropathy is a major complication of diabetes. Alterations of mesangial cells have
traditionally been the focus of research in deciphering molecular mechanisms of diabetic …

Diabetic kidney disease: pathophysiology and therapeutic targets

S Toth-Manikowski, MG Atta - Journal of diabetes research, 2015 - Wiley Online Library
Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD).
Over the past two decades, there has been significant clarification of the various pathways …

Diabetic nephropathy: diagnosis and treatment

D Fineberg, KAM Jandeleit-Dahm… - Nature Reviews …, 2013 - nature.com
Nephropathy remains a major cause of morbidity and a key determinant of mortality in
patients with type 1 or type 2 diabetes mellitus. Research is ongoing to identify biomarkers …