Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Iron is required for many biological processes but is also toxic in excess; thus, body iron
balance is maintained through sophisticated regulatory mechanisms. The lack of a regulated …

The Janus kinases (JAKs) are a family of intracellular tyrosine kinases that play an essential
role in the signaling of numerous cytokines that have been implicated in the pathogenesis of …

Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector
cytokines of the host immune response against viral infections. However, the production of …

Background Maternal inflammation during pregnancy increases the risk for offspring
psychiatric disorders and other adverse long-term health outcomes. The influence of …

Transforming growth factor-β (TGF-β) is widely recognized as a core pathway of fibrosis.
Inhibition of TGF-β signaling may thus offer potential for antifibrotic therapies. Long-term …

Despite advances in the treatment of psoriasis, there is an unmet need for effective and safe
oral treatments. The Janus Kinase–Signal Transducer and Activator of Transcription (JAK …

The JAK–STAT signal transduction pathway is responsible for mediating signals of over fifty
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …

Inhibitors of the JAK family of nonreceptor tyrosine kinases have demonstrated clinical
efficacy in rheumatoid arthritis and other inflammatory disorders; however, the precise …

Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that
results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in …