MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression
post-transcriptionally. As a consequence of their function towards mRNA, miRNAs are …

During the last decade, it has become clear that aberrant microRNA expression has a
functional role in the initiation and progression of colorectal cancer (CRC). Specific …

Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present
study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to …

Background/Aims: MicroRNA-21 (miR-21) has been demonstrated to play an important role
in carcinogenesis; however, its mechanism of action in colorectal cancer (CRC) has not …

MicroRNAs (miRNAs) are small, endogenous, noncoding RNAs, shown to be expressed
abnormally in many tumors and identified as predictive biomarkers for early diagnosis of …

As the area of small molecules interacting with RNA advances, general routes to provide
bioactive compounds are needed as ligands can bind RNA avidly to sites that will not affect …

In the early years of the molecular biology revolution, cancer research was mainly focused
on genetic changes (ie, those that altered DNA sequences). Although this has been …

Abstract Background MiR-221 and miR-222 (miR-221/222) are frequently up-regulated in
various types of human malignancy including glioblastoma. Recent studies have reported …

MicroRNAs (miRNAs) are small single-stranded RNAs that repress mRNA translation and
trigger mRNA degradation. Of the∼ 1900 miRNA-encoding genes present in the human …

Approximately 25% of all patients with stage II colorectal cancer will experience recurrent
disease and subsequently die within 5 years. MicroRNA-21 (miR-21) is upregulated in …