Deuterium‐and tritium‐labelled compounds: applications in the life sciences

J Atzrodt, V Derdau, WJ Kerr… - Angewandte chemie …, 2018 - Wiley Online Library
Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …

Apolipoprotein E binding drives structural and compositional rearrangement of mRNA-containing lipid nanoparticles

F Sebastiani, M Yanez Arteta, M Lerche, L Porcar… - ACS …, 2021 - ACS Publications
Emerging therapeutic treatments based on the production of proteins by delivering mRNA
have become increasingly important in recent times. While lipid nanoparticles (LNPs) are …

[HTML][HTML] Small-angle scattering techniques for peptide and peptide hybrid nanostructures and peptide-based biomaterials

IW Hamley, V Castelletto - Advances in Colloid and Interface Science, 2023 - Elsevier
The use of small-angle scattering (SAS) in the study of self-assembly of peptides and
peptide conjugates (lipopeptides, polymer-peptide conjugates and others) is reviewed …

A molecular mechanism for transthyretin amyloidogenesis

AW Yee, M Aldeghi, MP Blakeley, A Ostermann… - Nature …, 2019 - nature.com
Human transthyretin (TTR) is implicated in several fatal forms of amyloidosis. Many
mutations of TTR have been identified; most of these are pathogenic, but some offer …

Small-angle neutron scattering contrast variation studies of biological complexes: Challenges and triumphs

S Krueger - Current opinion in structural biology, 2022 - Elsevier
Small-angle neutron scattering (SANS) has been a beneficial tool for studying the structure
of biological macromolecules in solution for several decades. Continued improvements in …

Biological small-angle neutron scattering: recent results and development

E Mahieu, F Gabel - Acta Crystallographica Section D: Structural …, 2018 - journals.iucr.org
Small-angle neutron scattering (SANS) has increasingly been used by the structural biology
community in recent years to obtain low-resolution information on solubilized …

Deuterium‐und tritiummarkierte Verbindungen: Anwendungen in den modernen Biowissenschaften

J Atzrodt, V Derdau, WJ Kerr, M Reid - Angewandte Chemie, 2018 - Wiley Online Library
Wasserstoffisotope sind einzigartige Werkzeuge zur Identifizierung und Erforschung
biologischer oder chemischer Vorgänge. Wasserstoffisotopenmarkierungen erlauben den …

Conformational states of ABC transporter MsbA in a lipid environment investigated by small-angle scattering using stealth carrier nanodiscs

I Josts, J Nitsche, S Maric, HD Mertens, M Moulin… - Structure, 2018 - cell.com
Structural studies of integral membrane proteins (IMPs) are challenging, as many of them
are inactive or insoluble in the absence of a lipid environment. Here, we describe an …

Neutron scattering in the biological sciences: progress and prospects

R Ashkar, H Bilheux, H Bordallo, R Briber… - … Section D: Structural …, 2018 - journals.iucr.org
The scattering of neutrons can be used to provide information on the structure and dynamics
of biological systems on multiple length and time scales. Pursuant to a National Science …

Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding

L Gajdos, MP Blakeley, M Haertlein, VT Forsyth… - Nature …, 2022 - nature.com
The opportunistic pathogen Pseudomonas aeruginosa, a major cause of nosocomial
infections, uses carbohydrate-binding proteins (lectins) as part of its binding to host cells …