As humans evolved, perhaps the two strongest selection determinants of survival were a
robust immune response able to clear bacterial, viral, and parasitic infection and an ability to …

Obesity is characterized by the chronic low-grade activation of the innate immune system. In
this respect, macrophage-elicited metabolic inflammation and adipocyte-macrophage …

In mammals, liver is a central organ for controlling the metabolic homeostasis for
carbohydrates, lipid, and proteins. Dysregulation of liver functions could lead to the …

Lipids are vital components of many biological processes and crucial in the pathogenesis of
numerous common diseases, but the specific mechanisms coupling intracellular lipids to …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
Western countries and is considered the hepatic manifestation of metabolic syndrome. The …

This review focuses on adipose tissue biology and introduces the concept of adipose tissue
plasticity and expandability as key determinants of obesity-associated metabolic …

Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic
intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 …

The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …

PCOS is not only the most frequent cause of oligomenorrhea in young women, but also a
metabolic disorder characterized by insulin resistance, glucose intolerance, dyslipidemia …

Although counterregulatory hormones and mediators of the fight-or-flight responses are well
defined at many levels, how energy stores per se are integrated into this system remains an …