Transient receptor potential canonical (TRPC) channels: then and now
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
Small molecules targeting canonical transient receptor potential channels: an update
H Liu, M Fu, Y Zhang, Q You, L Wang - Drug discovery today, 2024 - Elsevier
Transient receptor potential canonical (TRPC) channels belong to an important class of non-
selective cation channels. This channel family consists of multiple members that widely …
selective cation channels. This channel family consists of multiple members that widely …
Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice
W Zhong, M Ma, J Xie, C Huang, X Li, M Gao - Nature Communications, 2023 - nature.com
Chronic inflammation of white adipose tissue is a key link between obesity and the
associated metabolic syndrome. Transient receptor potential melastatin-like 7 (TRPM7) is …
associated metabolic syndrome. Transient receptor potential melastatin-like 7 (TRPM7) is …
Pharmacology of TRPC channels and its potential in cardiovascular and metabolic medicine
RS Bon, DJ Wright, DJ Beech… - Annual review of …, 2022 - annualreviews.org
Transient receptor potential canonical (TRPC) proteins assemble to form homo-or
heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC …
heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC …
Involvement of calcium channels in the regulation of adipogenesis
M Zhai, D Yang, W Yi, W Sun - Adipocyte, 2020 - Taylor & Francis
As an important second messenger in adipocytes, calcium ions (Ca2+) are essential in
regulating various intracellular signalling pathways that control critical cellular functions …
regulating various intracellular signalling pathways that control critical cellular functions …
Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease
Proteins of the TRPC family can form many homo-and heterotetrameric cation channels
permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the …
permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the …
[HTML][HTML] Dysregulation of autophagy acts as a pathogenic mechanism of non-alcoholic fatty liver disease (NAFLD) induced by common environmental pollutants
Y Zhang, K Li, A Kong, Y Zhou, D Chen, J Gu… - … and Environmental Safety, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has been the most common chronic liver disease
in the world, including the developing countries. NAFLD is metabolic disease with significant …
in the world, including the developing countries. NAFLD is metabolic disease with significant …
Treasure troves of pharmacological tools to study transient receptor potential canonical 1/4/5 channels
HN Rubaiy - British Journal of Pharmacology, 2019 - Wiley Online Library
Canonical or classical transient receptor potential 4 and 5 proteins (TRPC4 and TRPC5)
assemble as homomers or heteromerize with TRPC1 protein to form functional nonselective …
assemble as homomers or heteromerize with TRPC1 protein to form functional nonselective …
A diet high in carotenoid-rich vegetables and fruits favorably impacts inflammation status by increasing plasma concentrations of IFN-α2 and decreasing MIP-1β and …
L Jahns, Z Conrad, LAK Johnson, LD Whigham, D Wu… - Nutrition research, 2018 - Elsevier
The health benefits of vegetable and fruit (VF) intake include benefits for diseases that have
an inflammatory component, although the relationship between VF intake and systemic …
an inflammatory component, although the relationship between VF intake and systemic …
The mechanisms of exercise improving cardiovascular function by stimulating Piezo1 and TRP ion channels: a systemic review
X Duan, R Liu, Y Xi, Z Tian - Molecular and Cellular Biochemistry, 2024 - Springer
Mechanosensitive ion channels are widely distributed in the heart, lung, bladder and other
tissues, and plays an important role in exercise-induced cardiovascular function promotion …
tissues, and plays an important role in exercise-induced cardiovascular function promotion …