α, α‐Difluoroketones are valuable compounds and can be used as synthetic intermediates
for the synthesis of fluorinated molecules, but they also have a direct application in …

The α, α‐dihalocarbonyl moiety is a bifunctional system with a gem‐dihalocarbon and a
carbonyl carbon in 1, 2‐fashion. This is one of the privileged scaffolds in medicinal chemistry …

A reaction manifold has been discovered in which the chemoselectivity can be altered by
switching between neat milling and liquid assisted grinding (LAG) with polar additives. After …

CF2H groups are unique due to the combination of their lipophilic and hydrogen bonding
properties. The strength of H-bonding is determined by the group to which it is appended …

The homologation of Weinreb amides into difluoromethylketones with a formal nucleophilic
CHF2 transfer agent is reported. Activating TMSCHF2 with potassium tert-amylate enables a …

The deprotonative functionalization of α, α‐difluoromethyl ketones is described herein.
Using a catalytic organosuperbase and a silane additive, the corresponding difluoroenolate …

Regioselective α, α-difunctionalization adjacent to a ketone is a significant synthetic
challenge. Here, we present a solution to this problem through the transition-metal-free …

A simple and straightforward approach to the synthesis of trifluoromethyl and difluoromethyl
ketones from widely available carboxylic acids is disclosed. The transformation utilizes an …

Methods for the fluorination of organoboron compounds are described. This review will
cover the fluorination of aromatic and aliphatic systems using both electrophilic and …

A facile synthetic approach to a series of difluoromethyl ketones from β‐ketoacids has been
described. This transformation is achieved through the straightforward decarboxylative …