Abstract This International Consensus Classification and Nomenclature for the congenital
bicuspid aortic valve condition recognizes 3 types of bicuspid valves: 1. The fused type (right …

Strategies to optimize clinical genetic diagnostic pathways by combining both targeted and
next-generation sequencing are discussed. In addition to improved genetic counseling …

Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

In 2005, Bart Loeys and Harry Dietz described a new syndromic aneurysmal entity. Its
patients were typically characterized by a clinical triad that included hypertelorism (widely …

Medium-sized and large arteries consist of 3 layers: the tunica intima, tunica media, and
tunica adventitia. The tunica media accounts for the bulk of the vessel wall and is the chief …

Bicuspid aortic valve (BAV) is the most common congenital heart defect, found in up to 2% of
the population and associated with a 30% lifetime risk of complications. BAV is inherited as …

Thoracic aortic aneurysm is a typically silent disease characterized by a lethal natural
history. Since the discovery of the familial nature of thoracic aortic aneurysm and dissection …

Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

Thoracic aortic aneurysms, with an estimated prevalence in the general population of 1%,
are potentially lethal, via rupture or dissection. Over the prior two decades, there has been …

Congenital heart disease (CHD) is the most common major congenital anomaly with an
incidence of∼ 1% of live births and is a significant cause of birth defect–related mortality …