Focal cerebral ischaemia and post-ischaemic reperfusion cause cerebral capillary
dysfunction, resulting in oedema formation and haemorrhagic conversion. There are …

Stroke is an acute cerebrovascular disease caused by sudden rupture of blood vessels in
the brain or blockage of blood vessels, which has now become one of the main causes of …

Introduction Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer
with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is associated with …

Acute neurological conditions such as cerebrovascular diseases and trauma are associated
with irreversible loss of neurons and glial cells. Severe or prolonged injury results in …

Summary Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional factor. Under normal
oxygen tension, HIF-1 activity is usually suppressed due to the rapid, oxygen-dependent …

Brain ischemia is one of the leading causes of disability and mortality worldwide. Nitric oxide
(NO•), a molecule that is involved in the regulation of proper blood flow, vasodilation …

Introduction: Obstructive sleep apnea (OSA) is a serious and prevalent medical condition
with major consequences for health and safety. Excessive daytime sleepiness (EDS) is a …

Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by various intra‐
and extrapulmonary injury factors. Presently, excessive inflammation in the lung and the …

A divergence in the supply and consumption of oxygen in brain tissue initiates complex
cycle of biochemical and molecular events resulting in neuronal death. To overcome such …

Puerarin, a major isoflavonoid derived from the Chinese medical herb Radix puerariae
(kudzu root), has been reported to be useful in the treatment of various cardiovascular …