Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences

F Pazan, M Wehling - European geriatric medicine, 2021 - Springer
Background The number of older adults has been constantly growing around the globe.
Consequently, multimorbidity and related polypharmacy have become an increasing …

Multisystem physiological perspective of human frailty and its modulation by physical activity

JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Physical frailty: ICFSR international clinical practice guidelines for identification and management

E Dent, JE Morley, AJ Cruz-Jentoft… - The journal of nutrition …, 2019 - Springer
Objective The task force of the International Conference of Frailty and Sarcopenia Research
(ICFSR) developed these clinical practice guidelines to overview the current evidence-base …

[HTML][HTML] Underrepresentation of the elderly in clinical trials, time for action

RJ van Marum - British Journal of Clinical Pharmacology, 2020 - ncbi.nlm.nih.gov
In the general population, the use of prescription drugs increases with age. European data
show that 46% of the European population in the age group 45–54 years use prescribed …

Polypharmacy in elderly people

P Dovjak - Wiener Medizinische Wochenschrift, 2022 - Springer
Polypharmacy characterizes ongoing prescription of multiple medications in a patient.
Following the demographic change and growing number of elderly patients, polypharmacy …

Exercise to prevent and manage frailty and fragility fractures

E Dent, RM Daly, EO Hoogendijk, D Scott - Current osteoporosis reports, 2023 - Springer
Abstract Purpose of Review This review identifies exercise-based recommendations to
prevent and manage frailty and fragility fractures from current clinical practice guidelines. We …

Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: a systematic review and meta-analysis

JJY Toh, H Zhang, YY Soh, Z Zhang, XV Wu - Ageing research reviews, 2023 - Elsevier
Polypharmacy is a prevalent issue in older adults, associated with a wide range of adverse
health outcomes, amplified in those with frailty. This review aims to synthesize current …

Medication management in frail older people: consensus principles for clinical practice, research, and education

SJ Liau, S Lalic, JK Sluggett, M Cesari, G Onder… - Journal of the American …, 2021 - Elsevier
Frailty is a geriatric condition associated with increased vulnerability to adverse drug events
and medication-related harm. Existing clinical practice guidelines rarely provide medication …

Association between frailty and ischemic heart disease: a systematic review and meta-analysis

R Liperoti, DL Vetrano, K Palmer, T Targowski… - BMC geriatrics, 2021 - Springer
Background Frailty is increasingly reported among older adults with cardiovascular diseases
and it has been demonstrated to increase negative health outcomes and mortality. To date …

Aging and the prevalence of polypharmacy and hyper-polypharmacy among older adults in South Korea: a national retrospective study during 2010–2019

HJ Cho, J Chae, SH Yoon, DS Kim - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Polypharmacy has become a global health problem and is associated with
adverse health outcomes in the elderly. This study evaluated the prevalence of …